Halfway by means of his career, Cees Dekker reinvented himself. Immediately after a long time of hardcore physics, he shifted his concentrate to ‘nanobiology’ for the flip of the millennium. A expression he coined himself, as being a subject of fact.

Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transportation of macromolecules

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Non-equilibrium folding of specific DNA molecules recaptured approximately one thousand moments in the reliable condition nanopore

2010, produced a different way (‘wedging transfer’) to govern nanostructures; first report of DNA translocation via graphene nanopores; and realized hybrid nanopores by directed insertion of α-hemolysin into reliable-condition nanopores

Our study ranges in the biophysics of DNA to synthetic cells and beyond. Please have a look down below at the spectrum of our current jobs.

All parameters had been precisely the same for every panel During this video, except for the initial placement on the 6hb rod (demonstrated in blue) to the nanopore. Simulations that terminated early due to translocation of the rod with the pore are marked by a grey track record.

Finding out DNA loop extrusion by SMC proteins for chromosome architecture with single-molecule assays.

2003, shown the 1st biosensors designed away from a carbon nanotube; settled the structure and system of DNA repair service proteins; and discovery of a different strategy for fabricating sound-condition nanopores for DNA translocation

Really neat, but that wasn’t truly wherever my interest lay. I wished to pioneer And that i experienced the feeling that was no more probable, because the most intriguing essential insights experienced currently been uncovered. But my subject experienced created a lot of remarkable new resources to measure particular person molecules. I made a decision that I desired to use this to biology, to take a look at it from the Actual physical point of view.’

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It absolutely was an extremely attention-grabbing ceesdekker time, throughout which I acquired many assistance from Delft University of Know-how, exactly where I used to be a professor at some time, and I started off several collaborations with molecular biologists. That assisted me master a good deal.’